期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms21093387
关键词
B-cell malignancies; tumor microenvironment; stroma; microRNAs; cell-to-cell communication; exosomal miRNAs; immune cells; endothelial cells; cancer-associated fibroblasts
资金
- NIH/NCATS through the NIH Common Fund [UH3TR00943-01]
- Office of Strategic Coordination, NCI [1R01 CA182905-01, 1R01CA222007-01A1]
- NIGMS [1R01GM122775-01]
- NIH U54 grant [CA096297, CA096300]
- University of Puerto Rico/The University of Texas MD Anderson Cancer Center Partnership for Excellence in Cancer Research Pilot Project, Team Department of Defense grant [CA160445P1]
- MD Anderson Cancer Center Chronic Lymphocytic Leukemia Moon Shot Flagship project
- Sister Institution Network Fund grant
An increased focus is being placed on the tumorigenesis and contexture of tumor microenvironment in hematopoietic and solid tumors. Despite recent clinical revolutions in adoptive T-cell transfer approaches and immune checkpoint blockade, tumor microenvironment is a major obstacle to tumor regression in B-cell malignancies. A transcriptional alteration of coding and non-coding RNAs, such as microRNAs (miRNAs), has been widely demonstrated in the tumor microenvironment of B-cell malignancies. MiRNAs have been associated with different clinical-biological forms of B-cell malignancies and involved in the regulation of B lymphocyte development, maturation, and function, including B-cell activation and malignant transformation. Additionally, tumor-secreted extracellular vesicles regulate recipient cell functions in the tumor microenvironment to facilitate metastasis and progression by delivering miRNA contents to neighboring cells. Herein, we focus on the interplay between miRNAs and tumor microenvironment components in the different B-cell malignancies and its impact on diagnosis, proliferation, and involvement in treatment resistance.
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