期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ijms21072613
关键词
JNK; C-JUN N-terminal kinase; stem cell; cancer stem cell; stem cell niche; tumor microenvironment; WNT; NOTCH1
资金
- Breast Cancer Research Foundation [BCRF-17-161]
- Morgan Welch Inflammatory Breast Cancer Research Program and Clinic
- State of Texas Rare and Aggressive Breast Cancer Research Program
- National Institutes of Health [1R01CA205043-01A1]
- NIH [GM123252]
- Cancer Prevention and Research Institute of Texas [RP160657, RP180880]
- Welch Foundation [F-1390]
C-JUN N-terminal kinases (JNKs), which belong to the mitogen-activated protein kinase (MAPK) family, are evolutionarily conserved kinases that mediate cell responses to various types of extracellular stress insults. They regulate physiological processes such as embryonic development and tissue regeneration, playing roles in cell proliferation and programmed cell death. JNK signaling is also involved in tumorigenesis and progression of several types of malignancies. Recent studies have shown that JNK signaling has crucial roles in regulating the traits of cancer stem cells (CSCs). Here we describe the functions of the JNK signaling pathway in self-renewal and differentiation, which are essential features of various types of stem cells, such as embryonic, induced pluripotent, and adult tissue-specific stem cells. We also review current knowledge of JNK signaling in CSCs and discuss its role in maintaining the CSC phenotype. A better understanding of JNK signaling as an essential regulator of stemness may provide a basis for the development of regenerative medicine and new therapeutic strategies against malignant tumors.
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