期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ijms21072581
关键词
phosphoinositides; phospholipase C; cancer; phosphatidylinositol
资金
- Italian PRIN-MIUR grants
- Intesa S. Paolo Foundation
- Fondazione Cassa di Risparmio di Bologna
- Fondazione del Monte di Bologna e Ravenna grant
- China Scholarship Council [201708510140]
Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but are significantly involved in cancer development and progression. In several cancer types, phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P-3] and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P-2] play significant roles in regulating survival, proliferation, invasion, and growth of cancer cells. Phosphoinositide-specific phospholipase C (PLC) catalyze the generation of the essential second messengers diacylglycerol (DAG) and inositol 1,4,5 trisphosphate (InsP(3)) by hydrolyzing PtdIns(4,5)P-2. DAG and InsP(3) regulate Protein Kinase C (PKC) activation and the release of calcium ions (Ca2+) into the cytosol, respectively. This event leads to the control of several important biological processes implicated in cancer. PLCs have been extensively studied in cancer but their regulatory roles in the oncogenic process are not fully understood. This review aims to provide up-to-date knowledge on the involvement of PLCs in cancer. We focus specifically on PLC beta, PLC gamma, PLC delta, and PLC epsilon isoforms due to the numerous evidence of their involvement in various cancer types.
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