期刊
CEREBRAL CORTEX
卷 27, 期 11, 页码 5156-5169出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhw297
关键词
association cortex; default mode network; frontoparietal control network; resting state; sensory cortex
资金
- National Institutes of Health [DP50D012109-03, T32GM 007205, MH43775, MH077945, MH074797]
- National Institute on Alcohol Abuse and Alcoholism [2P50AA012870-11]
- National Institute of Mental Health [F30 MH107149]
Schizophrenia (SCZ) is a disabling neuropsychiatric disease associated with disruptions across distributed neural systems. Resting-state functional magnetic resonance imaging has identified extensive abnormalities in the blood-oxygen level-dependent signal in SCZ patients, including alterations in the average signal over the brain-i.e. the global signal (GS). It remains unknown, however, if these global alterations occur pervasively or follow a spatially preferential pattern. This study presents the first network-by-network quantification of GS topography in healthy subjects and SCZ patients. We observed a nonuniform GS contribution in healthy comparison subjects, whereby sensory areas exhibited the largest GS component. In SCZ patients, we identified preferential GS representation increases across association regions, while sensory regions showed preferential reductions. GS representation in sensory versus association cortices was strongly anti-correlated in healthy subjects. This anti-correlated relationship was markedly reduced in SCZ. Such shifts in GS topography may underlie profound alterations in neural information flow in SCZ, informing development of pharmacotherapies.
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