期刊
CEREBRAL CORTEX
卷 27, 期 2, 页码 1439-1456出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhv329
关键词
evolution; grasping; motor cortex; primate; reaching
资金
- NIH NINDS [NS035103, F32 NS093721-01]
- NIH NEI [T23 EY015387]
Long-train intracortical microstimulation (LT-ICMS) is a popular method for studying the organization of motor and posterior parietal cortex (PPC) in mammals. In primates, LT-ICMS evokes both multijoint and multiple-body-part movements in primary motor, premotor, and PPC. In rodents, LT-ICMS evokes complexmovements of a single limb in motor cortex. Unfortunately, very little is known about motor/ PPC organization in other mammals. Tree shrews are closely related to both primates and rodents and could provide insights into the evolution of complex movement domains in primates. The present study investigated the extent of cortex in which movements could be evoked with ICMS and the characteristics of movements elicited using both short train (ST) and LT-ICMS in tree shrews. We demonstrate that LT-ICMS and ST-ICMS maps are similar, with the movements elicited with ST-ICMS being truncated versions of those elicited with LT-ICMS. In addition, LT-ICMS-evoked complex movements within motor cortex similar to those in rodents. More complex movements involving multiple body parts such as the hand and mouth were also elicited in motor cortex and PPC, as in primates. Our results suggest that complex movement networks present in PPC and motor cortex were present in mammals prior to the emergence of primates.
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