期刊
CEREBRAL CORTEX
卷 27, 期 3, 页码 1779-1794出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhw010
关键词
entorhinal cortex; hippocampus; human circuitry; perforant pathway; polarized light microscopy
资金
- Burroughs Wellcome Fund Collaborative Research Travel Grant
- European Union [604102]
- Portfolio Theme Supercomputing and Modeling for the Human Brain of the Helmholtz Association, Germany
- National Institutes of Health [R01 MH092311]
While hippocampal connectivity is essential to normal memory function, our knowledge of human hippocampal circuitry is largely inferred from animal studies. Using polarized light microscopy at 1.3 mu m resolution, we have directly visualized the 3D course of key medial temporal pathways in 3 ex vivo human hemispheres and 2 ex vivo vervet monkey hemispheres. The multiple components of the perforant path system were clearly identified: Superficial sheets of fibers emanating from the entorhinal cortex project to the presubiculum and parasubiculum, intermixed transverse and longitudinal angular bundle fibers perforate the subiculum and then project to the cornu ammonis (CA) fields and dentate molecular layer, and a significant alvear component runs from the angular bundle to the CA fields. From the hilus, mossy fibers localize to regions of high kainate receptor density, and the endfolial pathway, mostly investigated in humans, merges with the Schaffer collaterals. This work defines human hippocampal pathways underlying mnemonic function at an unprecedented resolution.
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