4.3 Review

ADAMTS-5: A difficult teenager turning 20

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Matrix-degrading protease ADAMTS-5 cleaves inter-?-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

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IN VITRO CHARACTERIZATION OF THE ADAMTS-5 SPECIFIC NANOBODY® M6495

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OSTEOARTHRITIS AND CARTILAGE (2018)

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Functional role of ADAMTS5 in adiposity and metabolic health

Dries Bauters et al.

PLOS ONE (2018)

Article Multidisciplinary Sciences

The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness

Yasmin et al.

SCIENTIFIC REPORTS (2018)

Article Medicine, Research & Experimental

Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection

Frank S. Cikach et al.

JCI INSIGHT (2018)

Article Medicine, Research & Experimental

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

Rachel E. Miller et al.

JCI INSIGHT (2018)

Article Cardiac & Cardiovascular Systems

Gene expression profiling of acute type A aortic dissection combined with in vitro assessment

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Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

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GLPG1972: A POTENT, SELECTIVE, ORALLY AVAILABLE ADAMTS-5 INHIBITOR FOR THE TREATMENT OF OA

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ADAMTS and ADAM metalloproteinases in osteoarthritis-looking beyond the 'usual suspects'

C. -Y. Yang et al.

OSTEOARTHRITIS AND CARTILAGE (2017)

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Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis

Keiichi Asano et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers

Hansen J. Kosasih et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Gastroenterology & Hepatology

ADAMTS5 deficiency protects against non-alcoholic steatohepatitis in obesity

Dries Bauters et al.

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ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity

Meagan McMahon et al.

PLOS BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

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BIOCHEMICAL JOURNAL (2015)

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Moving targets: Emerging roles for MMPs in cancer progression and metastasis

Gemma Shay et al.

MATRIX BIOLOGY (2015)

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Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification

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OSTEOARTHRITIS AND CARTILAGE (2015)

Article Chemistry, Medicinal

Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma

Chongyi Li et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2015)

Article Clinical Neurology

Genetic susceptibility of lumbar degenerative disc disease in young Indian adults

S. Rajasekaran et al.

EUROPEAN SPINE JOURNAL (2015)

Article Biochemistry & Molecular Biology

Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5

Simon J. Foulcer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biotechnology & Applied Microbiology

ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury

Kadir Demircan et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Biochemistry & Molecular Biology

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage

Kazuhiro Yamamoto et al.

FASEB JOURNAL (2013)

Article Medicine, Research & Experimental

Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis

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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

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Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves

Loren E. Dupuis et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)

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ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy

Rebecca Bell et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2013)

Article Biochemistry & Molecular Biology

Novel Role of ADAMTS-5 Protein in Proteoglycan Turnover and Lipoprotein Retention in Atherosclerosis

Athanasios Didangelos et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Orthopedics

Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5

Vincent M. Wang et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2012)

Article Developmental Biology

Altered versican cleavage in ADAMTS5 deficient mice; A novel etiology of myxomatous valve disease

Loren E. Dupuis et al.

DEVELOPMENTAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Pericellular Versican Regulates the Fibroblast-Myofibroblast Transition A ROLE FOR ADAMTS5 PROTEASE-MEDIATED PROTEOLYSIS

Noriko Hattori et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Rheumatology

The role of the cartilage matrix in osteoarthritis

Dick Heinegard et al.

NATURE REVIEWS RHEUMATOLOGY (2011)

Article Geriatrics & Gerontology

Epidemiology of Osteoarthritis

Yuqing Zhang et al.

CLINICS IN GERIATRIC MEDICINE (2010)

Article Biochemistry & Molecular Biology

Leptin plays a catabolic role on articular cartilage

Jia-peng Bao et al.

MOLECULAR BIOLOGY REPORTS (2010)

Editorial Material Medicine, Research & Experimental

Ligation of TLR2 by Versican: A Link Between Inflammation and Metastasis

Wei Wang et al.

ARCHIVES OF MEDICAL RESEARCH (2009)

Article Otorhinolaryngology

INCREASED mRNA EXPRESSION OF ADAMTS METALLOPROTEINASES IN METASTATIC FOCI OF HEAD AND NECK CANCER

Kadir Demircan et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2009)

Article Biochemistry & Molecular Biology

Characterization of proADAMTS5 processing by proprotein convertases

Jean-Michel Longpre et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Review Immunology

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

Janusz Wesolowski et al.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2009)

Article Multidisciplinary Sciences

Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor

Masashi Akiyama et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Rheumatology

Characterization of metalloprotease cleavage products of human articular cartilage

Eugene Y. Zhen et al.

ARTHRITIS AND RHEUMATISM (2008)

Article Biochemistry & Molecular Biology

The first but not the second thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis inhibitor

Soheila Sharghi-Namini et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Oncology

BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion

Mariano Sebastian Viapiano et al.

JOURNAL OF NEURO-ONCOLOGY (2008)

Article Biochemistry & Molecular Biology

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity

Kazunari Fushimi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Rheumatology

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States

Charles G. Helmick et al.

ARTHRITIS AND RHEUMATISM (2008)

Article Pathology

Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage

Satoko Naito et al.

PATHOLOGY INTERNATIONAL (2007)

Article Biochemistry & Molecular Biology

Proteolytic activities of human ADAMTS-5 - Comparative studies with ADAMTS-4

Christi Gendron et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Medicine, Research & Experimental

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

Christopher B. Little et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan

Charlotte J. East et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Anatomy & Morphology

Versican proteolysis mediates myocardial. regression during outflow tract development

Christine B. Kern et al.

DEVELOPMENTAL DYNAMICS (2007)

Article Medicine, Research & Experimental

Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members

Jennifer M. MacArthur et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development

Gabor Voros et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)

Article Orthopedics

The cleavage of biglycan by aggrecanases

L. I. Melching et al.

OSTEOARTHRITIS AND CARTILAGE (2006)

Article Biochemistry & Molecular Biology

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: Comparative analyses with ADAMTS-5,-9,-16 and-18

WL Zeng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)

Article Cell Biology

Expression of versican and ADAMTS1, 4, and 5 during bone development in the rat mandible and hind limb

M Nakamura et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1

NV Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Clinical Neurology

Human glioblastomas overexpress ADAMTS-5 that degrades brevican

M Nakada et al.

ACTA NEUROPATHOLOGICA (2005)

Article Multidisciplinary Sciences

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

H Stanton et al.

NATURE (2005)

Article Hematology

Role of ADAMTS-1 in atherosclerosis - Remodeling of carotid artery, immunohistochemistry, and proteolysis of versican

AC Jonnsson-Rylander et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

α2-Macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes

MD Tortorella et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

M Kashiwagi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Neurosciences

Regeneration beyond the glial scar

J Silver et al.

NATURE REVIEWS NEUROSCIENCE (2004)

Article Rheumatology

Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

SS Glasson et al.

ARTHRITIS AND RHEUMATISM (2004)

Article Biochemistry & Molecular Biology

ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage

LA Collins-Racie et al.

MATRIX BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Matrix proteoglycans are markedly affected in advanced laryngeal squamous cell carcinoma

SS Skandalis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2004)

Article Rheumatology

Expression profiling of metalloproteinases and their inhibitors in cartilage

L Kevorkian et al.

ARTHRITIS AND RHEUMATISM (2004)

Review Cardiac & Cardiovascular Systems

Proteoglycans in atherosclerosis and restenosis - Key roles for versican

TN Wight et al.

CIRCULATION RESEARCH (2004)

Article Biochemistry & Molecular Biology

Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis

P Lorenzo et al.

MATRIX BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Aggrecan protects cartilage collagen from proteolytic cleavage

MA Pratta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1

RPT Somerville et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-α, TNF-α converting enzyme and ADAMTS family members in murine fat territories

G Voros et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2003)

Article Hematology

Human coronary smooth muscle cells internalize versican-modified LDL through LDL receptor-related protein and LDL receptors

V Llorente-Cortes et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)

M Kashiwagi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage

P Patwari et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)