期刊
INTERNATIONAL JOURNAL OF CANCER
卷 147, 期 7, 页码 1845-1854出版社
WILEY
DOI: 10.1002/ijc.32963
关键词
accelerometry; bone; bone mineral density; bone health; childhood cancer survivors; densitometry; DXA; high impact load; physical activity; pQCT
类别
资金
- Swiss Cancer League [KLS-3175-02-2013]
- Stiftung fur krebskranke Kinder, Regio Basiliensis
- Gedachtnis-Stiftung Susy Ruckert zur Krebsbekampfung
- Taecker-Stiftung fur Krebsforschung
- Stiftung Henriette & Hans-Rudolf Dubach-Bucher
- Stiftung zur Krebsbekampfung
- Stiftung Krebs-Hilfe Zurich
- Fondation Recherche sur le Cancer de l'Enfant (FORCE)
- Fond'Action
- European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND) [609020]
Childhood cancer survivors (CCS) are at risk of reduced bone health and premature osteoporosis. As physical activity with high impact loading (IL-PA) is known to promote bone health, we compared bone densitometry and microstructure between groups of CCS who performed different amounts of physical activities in their daily life. We used baseline data of a single-center PA trial including 161 CCS from the Swiss Childhood Cancer Registry, aged <16 at diagnosis, >= 16 at study and >= 5 years since diagnosis. Lower body bone health was assessed with peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA). Daily IL-PA (duration in activities >2 g acceleration and numbers of vertical impacts/hr >2 g) was captured using hip-worn accelerometers (1-3 weeks). For both IL-PA approaches, we formed low, middle and high activity groups based on tertiles. Bone health of the high and middle active groups was compared to the low active group. 63% of CCS had indication of at least one bone mineral density z-score <= -1 measured by pQCT or DXA. The high IL-PA group performing 2.8 min/day or 19.1 impact peaks/hr > 2 g (median) showed about 3-13% better microstructural and densitometric bone health as compared to the low IL-PA group with 0.38 min/day or 0.85 peaks/hr > 2 g. Just a few minutes and repetitions of high IL-PA as easily modifiable lifestyle factor may be sufficient to improve bone health in adult CCS. Future longitudinal research is needed to better understand pattern and dosage of minimal impact loading needed to strengthen bone in growing and adult CCS.
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