Recent progress in development and chemical modification of poly (hydroxybutyrate)-based blends for potential medical applications

Poly(hydroxybutyrate) (PHB) has been considered as a promising biopolymer produced in certain microbes under specific fermentative and physiological conditions. Being less functional, hydrophobic and brittle, the processability of PHB is difficult which limits its widespread applications. However, its blends with suitable biopolymers, for instance biopolyesters, may impart in them desirable structural functionalities and properties, such as surface reactivity, amphiphilicity, controlled degradation and mechanical strength; thus making them inevitable candidates for biomedical applications. Herein, various chemical modification approaches have been discussed and analyzed including hydroxylation, aminolysis, block copolymerization (via either grafting or blending) with suitable biopolymers. The mentioned approaches may tune the mechanical and other desirable properties of resultant blends for value added biomedical applications particularly in drug delivery, tissue engineering and so on. Furthermore, some key areas have been highlighted where the future research may be focused. (C) 2020 Elsevier B.V. All rights reserved.