期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 148, 期 -, 页码 777-784出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.01.198
关键词
EGCG; Nanoparticles; Wound healing of diabetic mice
资金
- Anhui Natural Science Foundation [1908085MC74]
- Earmarked Fund for China Agriculture Research System [CARS-19]
- Chang-Jiang Scholars and the Innovative Research Team in University [IRT15R01]
The wounds of diabetic patients are difficult to heal, which could lead to a limb amputation or even death. The experiment aims to develop a new type of nanoparticles that could accelerate wound healing. Epigallocatechin gallate, ascorbic acid, gelatin and chitosan nanoparticles (EV NPS) were prepared by ion cross-linking method, and their properties were studied. The optimal formula ratio of EV NPS is Vc:EGCG:Gel:CS = 02:3:1:1. Transmission electron microscope (TEM) images show that it is a roughly uniform spherical nanopartide with a diameter of 200 nm. ICR mice were intraperitoneally injected with streptozocin (STZ) to establish diabetic mice. Full-thickness excisional wounds were established on the back of mice. The results showed that EV NPS can promote wound healing in diabetic mice, and the mechanism may be through increasing collagen accumulation, promoting angiogenesis and reducing the infiltration of inflammatory cells. EV NPS may have potential application values for wound healing in diabetic mice. (C) 2020 Elsevier B.V. All rights reserved.
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