期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 151, 期 -, 页码 757-780出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.02.217
关键词
Interfacing; DNA; Nanoparticles
资金
- Huxiang Young Talent Program of Hunan Province [2018RS3005]
- Project of Innovation-driven Plan in Central South University [2020CX048]
- Natural Science Foundation of Hunan Province, China [2019JJ60071]
- Shenghua Yuying Project of Central South University
- Postgraduate Independent Exploration and Innovation Project of Central South University [2019zzts1017]
- Undergraduate Innovation Project of Hunan Province [S201910533105]
- Key Research Fund of Hunan Provincial Education Department [18A211]
The knowledge on the mechanisms of DNA interfacing with nanopartides holds great potential for the design, assembly and usage of DNA in biological applications. A wave of understanding and exploitation of the mechanisms in DNA-nanopartides interfacial phenomenon has raised. Although some previous reviews have been reported, systematic and detailed reviews are rare. To achieve a better understanding of the mechanisms in the interaction between DNA and nanopartides, here, we summarized the recent progresses on the fundamental principles regarding the DNA-nanopartide interactions and their applications in biosensing. Special focus was put on inorganic nanoparticles such as metal nanoparticles, carbon-based materials, metal oxides and quantum dots. For each material, the surface properties, the interfacing mechanisms, and the kinetics and spatial control of DNA adsorption were summarized and discussed. We also highlighted some of the recent technologies based on DNA-NPs interactions for biomolecules detection. Finally, the challenges and future directions were discussed and proposed. This review provides a systematic understanding of the mechanisms in the interaction of DNA-nanoparticles, which, in turn, can inspire new insights for designing biosensors with improved properties. (C) 2020 Elsevier B.V. All rights reserved.
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