Preparation and characterization of carboxymethyl chitosan/collagen peptide/oxidized konjac composite hydrogel

Medical dressings are used to protect damaged skin from external factors and provide a good healing environment. Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water. It has been widely studied in the field of biomedical materials. In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible. Then, we set up different hydrogels and tested hydrogels with different proportions. The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM. The effects of hydrogels on the growth of NS-FB and HS-FB cells were studied in vitro. The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field. (C) 2020 Published by Elsevier B.