期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 149, 期 -, 页码 81-92出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.01.111
关键词
Algal polysaccharides; Structural characterization; Antidiabetic effects
资金
- State Key Research and Development Plan [2017YFD0400200]
- Guangdong Natural Science Foundation for Distinguished Young Scholar [2019B151502040]
- Guangzhou Science and Technology Plan Project [201710010060]
- Fundamental Research Funds for the Central Universities [2019ZD36]
Three algae polysaccharides (APs) extracted from Ascophyllum nodosum (ANP), Fucus vesiculosus (FVP) and Undaria Pinnatifida (USP) significantly differed in the zeta potential, water and oil holding capacity, monosaccharide composition, organic element composition, molecular weight distribution, microstructure and theological properties. Antidiabetic effects of APs were compared by oral intervention at the dose of 400 mg/kg . body weight/day in high sugar and fat diets and streptozotocin injection induced type 2 diabetic rats. The analysis of body weight, water intake, fasting blood glucose, insulin, oral glucose tolerance, blood lipid indicators (including total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and free fatty acid (ITA)), liver function indexes (involving alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and renal function profiles (comprising uric acid (UA) and urea nitrogen (BUN)) showed that APs possessed obvious antidiabetic activities, and FVP showed better effects in controlling the levels of FFA, AST, ALT, UA and BUN. Intervention of FVP reduced the total bile acid (TBA) level and elevated high density lipoprotein cholesterol (HDL-C) level of diabetic rats. Histomorphological observation further demonstrated that APs, especially FVP, could attenuate liver and kidney damage caused by diabetes. This study concluded that the antidiabetic effects of ANP, FVP and USP were distinctly different, which might be attributed to their different chemical structures. Therefore, the structure-activity relationship and antidiabetic mechanism of APs will be our future research direction. (C) 2020 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据