期刊
IMMUNOLOGICAL REVIEWS
卷 296, 期 1, 页码 24-35出版社
WILEY
DOI: 10.1111/imr.12859
关键词
B cell; germinal center; professional antigen-presenting cell; T follicular helper cell; Toll-like receptor; virus-like particle
类别
资金
- National Key Research and Development Program of China [2018YFA0900803]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB29050600]
- National Natural Science Foundation of China [31870882, 81991495]
B cells have been known for their ability to present antigens to T cells for almost 40 years. However, the precise roles of B cell antigen presentation in various immune responses are not completely understood. The term professional antigen-presenting cells (APCs) was proposed to distinguish APCs that are required for initiating the immune responses from those use antigen presentation to enhance their own effector functions. Unlike dendritic cells, which are defined as professional APCs for their well-established functions in activating naive T cells, B cells have been shown in the past to mostly present antigens to activated CD4+ T cells mainly to seek help from T helper cells. However, recent evidence suggested that B cells can act as professional APCs under infectious conditions or conditions mimicking viral infections. B cell antigen receptors (BCRs) and the innate receptor Toll-like receptors are activated synergistically in response to pathogens or virus-like particles, under which conditions B cells are not only potent but also the predominant APCs to turn naive CD4+ T cells into T follicular helper cells. The discovery of B cells as professional APCs to initiate CD4+ T cell response provides a new insight for both autoimmune diseases and vaccine development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据