期刊
IMMUNOLOGICAL INVESTIGATIONS
卷 49, 期 7, 页码 824-839出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08820139.2020.1752713
关键词
Cytokine; biodegradable microspheres; immune therapy
类别
资金
- Jewish Heritage Fund for Excellence Research Enhancement Grant Program at University of Louisville
Therapeutic macromolecules such as proteins are conventionally administered via bolus injection, an approach that presents significant limitations. Sustained-release biodegradable nano/microsphere depots, on the other hand, represent a more physiological delivery tool for biologics. Here, we focus on an emerging novel application of this technology, i.e., cytokine-encapsulated biodegradable microspheres as immune therapeutics. The overall pre-clinical experience, recent advances and the clinical potential of such formulations are discussed.
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