期刊
IET NANOBIOTECHNOLOGY
卷 14, 期 5, 页码 428-432出版社
WILEY
DOI: 10.1049/iet-nbt.2020.0106
关键词
radiation therapy; toxicology; gold; biomedical materials; nanofabrication; nanoparticles; iron compounds; cancer; nanomedicine; cellular biophysics; tumours; graphene compounds; biothermics; graphene oxide nanohybrid; combinatorial cancer treatment agent; cell toxicity assessment; MCF-7 cells; dose-dependent heat elevation; multifunctional cancer therapy agents; thermoradiotherapy agent; graphene oxide-iron oxide-gold nanoparticles; temperature measurement; radiofrequency wave; flow cytometry; time 40; 0 min; CO-FeO-Au
资金
- research council of Kermanshah University of Medical Sciences [980639]
The main focus of the current study is the fabrication of a multifunctional nanohybrid based on graphene oxide (GO)/iron oxide/gold nanoparticles (NPs) as the combinatorial cancer treatment agent. Gold and iron oxide NPs formed on the GONPs via the in situ synthesis approach. The characterisations showed that gold and iron oxide NPs formed onto the GO. Cell toxicity assessment revealed that the fabricated nanohybrid exhibited negligible toxicity against MCF-7 cells in low doses (<50 ppm). Temperature measurement showed a time and dose-dependent heat elevation under the interaction of the nanohybrid with the radio frequency (RF) wave. The highest temperature was recorded using 200 ppm concentration nanohybrid during 40 min exposure. The combinatorial treatments demonstrated that the maximum cell death (average of 53%) was induced with the combination of the nanohybrid with RF waves and radiotherapy (RT). The mechanistic study using the flow cytometry technique illustrated that early apoptosis was the main underlying cell death. Moreover, the dose enhancement factor of 1.63 and 2.63 were obtained from RT and RF, respectively. To sum up, the authors' findings indicated that the prepared nanohybrid could be considered as multifunctional and combinatorial cancer therapy agents.
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