期刊
BIOTECHNOLOGY LETTERS
卷 37, 期 9, 页码 1719-1727出版社
SPRINGER
DOI: 10.1007/s10529-015-1863-8
关键词
Bioengineering; miRNA; Regulation; Plant cell culture; Secondary metabolism; Small RNAs
资金
- Russian Science Foundation [14-14-00230]
- Russian Science Foundation [14-14-00230] Funding Source: Russian Science Foundation
Plant cell cultures are of particular interest in industrial applications as a source of biologically active substances. It is difficult, however, to achieve stable production of secondary metabolites for many plant cell cultures using classical techniques. Novel approaches should be developed for removal of the inhibitor blocks that prevent pathway activation and shift the regulatory balance to the activation of entire biosynthetic pathways. MicroRNAs (miRNAs) are small RNAs that play important regulatory roles in various biological processes. Only recently miRNAs have been demonstrated as active in secondary metabolism regulation. In this work, we summarize recent data on the emerging approaches based on regulation of secondary metabolism by miRNAs.
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