期刊
HUMAN BRAIN MAPPING
卷 41, 期 12, 页码 3305-3317出版社
WILEY
DOI: 10.1002/hbm.25018
关键词
cognitive functions; multidimensional functional connectivity patterns; partitioned heritability; psychiatric diseases; SNP-based heritability
资金
- National Natural Science Foundation of China [31730038]
- NSFC [NSFC 61621136008/DFG TRR-169]
- German Research Foundation (DFG) joint project [NSFC 61621136008/DFG TRR-169]
- Guangdong Pearl River Talents Plan Innovative and Entrepreneurial team grant [2016ZT06S220]
Resting-state functional connectivity profiles have been increasingly shown to be important endophenotypes that are tightly linked to human cognitive functions and psychiatric diseases, yet the genetic architecture of this multidimensional trait is barely understood. Using a unique sample of 1,704 unrelated, young and healthy Chinese Han individuals, we revealed a significant heritability of functional connectivity patterns in the whole brain and several subnetworks. We further proposed a partitioned heritability analysis for multidimensional functional connectivity patterns, which revealed the common and unique enrichment patterns of the genetic contributions to brain connectivity patterns for several gene sets linked to brain functions, including the genes expressed preferentially in the central nervous system and those associated with intelligence, educational attainment, attention-deficit/hyperactivity disorder, and schizophrenia. These results for the first time reveal the genetic architecture of multidimensional brain connectivity patterns across different networks and advance our understanding of the complex relationship between gene sets, neural networks, and behaviors.
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