期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 42, 期 8, 页码 2137-2144出版社
WILEY
DOI: 10.1002/hed.26151
关键词
chemoradiation; cisplatin; radiation; taxane
资金
- National Cancer Institute [1R01CA214825, 1R01CA218148, P30CA016672, P50CA097007]
- National Institute of Biomedical Imaging and Bioengineering [R25EB025787-01]
- National Institute of Dental and Craniofacial Research [1R01DE025248/R56DE025248]
- National Institutes of Health [NSF 1557679]
Background There is little data describing neurocognitive late sequelae in patients treated for oropharyngeal cancer. Methods Using PROs, scores for numbness/tingling and difficulty remembering were assessed. Wilcoxon testing was utilized to compare mean assessment scores (1-10) between treatment subgroups. Results Four-hundred ninety-seven patients were evaluated and 267 (54%) received chemotherapy. The mean score for numbness/tingling for patients receiving radiation alone was 0.99 and for each chemotherapy subgroup were: Induction chemotherapy (IC), 1.35 (n = 99); concurrent chemotherapy (CCRT), 1.04 (n = 111) and IC + CCRT, 2.48 (n = 57); 30% of patients who received IC + CCRT had scores >= 5. The mean scores for difficulty remembering were XRT: 1.44, chemotherapy: 1.45, and IC + CCRT subgroup: 2.42. Conclusions The symptom burden related to peripheral neuropathy and cognitive complaints was minimal. A minority of patients reported high burdens. Particularly, 30% of patients receiving IC + CCRT described moderate to severe numbness/tingling.
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