期刊
GYNECOLOGICAL ENDOCRINOLOGY
卷 36, 期 10, 页码 922-925出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2020.1725969
关键词
Natural killer cells; anti-Mullerian hormone; estradiol; recurrent implantation failure
资金
- National Research Foundation of Korea grant - Korean Government [NRF-2016R1D1A1B03933410, 2018R1D1A1B0704 8821]
Current knowledge of the association between peripheral natural killer (NK) cell proportion and ovarian function in reproductive-age women is limited. We explored the association between NK cell proportion and ovarian function in women who underwent in-vitro fertilization (IVF) treatment. This was a retrospective cohort study using the data of 20-44-year-old women with recurrent implantation failure (RIF) who were tested for NK cell proportion and anti-Mullerian hormone (AMH). Indicators of ovarian function included AMH, observed-to-(age-appropriate) reference AMH ratio, high FSH, peak E-2 and total number of oocytes during the first IVF cycle following the test. We used different model specification controlling for women's age, and body mass index. Among a total of 936 women, majority showed lower AMH compared to age-appropriate level. Average NK cell proportion was 13.5 +/- 5.7%. Number of oocytes showed positive association with NK cell (ss = 0.040, p = .025). In the subgroup with NK >= 18%, NK cell proportion was negatively associated with AMH (-0.106, p = .012), AMH ratio (-0.049, p = .014) and number of oocytes (-0.021, p < .001) while the associations with others remain close to null. High NK cell proportion may be harmful to ovarian reserve or function.
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