期刊
GROWTH HORMONE & IGF RESEARCH
卷 51, 期 -, 页码 27-33出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2020.01.005
关键词
Exercise; Colorectal surgery; Colorectal neoplasms; Insulin-like growth factor I; Insulin-like growth factor binding protein 3
资金
- AFA Insurance [150072]
- Swedish government [4307771, 718221, 784821]
- Swedish Cancer Society [CAN 2016/362]
- Mary von Sydow foundation [1216]
- Assar Gabrielssons Foundation [FB16-95, FB19-07]
- Region Vastra Gotaland [VGFOUREG-659011, 309261]
- Swedish Society of Medicine [SLS-499811]
- Gothenburg Medical Society [GLS-688001]
- Doctor Felix Neubergh's Foundation [2017-347]
- Lions Cancer Fund West [2019:6]
- Anna-Lisa and Bror Bjornsson's Foundation
- health and medical care committee of the regional executive board
Objectives: We report results from a subgroup within the ongoing PHYSSURG-C trial with the aim to examine effects of exercise on IGF-1 and IGFBP-3 in patients undergoing colorectal cancer surgery. Design: Randomised controlled trial. Setting: A Swedish university hospital. Participants: Between 2015 and 2016, 217 patients were enrolled (I = 106, C = 111), with 122 patients that had given blood samples at baseline and at least at one follow-up (I = 51, C = 71). Patients 20 year or older with colorectal cancer were eligible. Exclusion criteria were emergency surgery, local surgery, language problems or inability to perform intervention. Interventions: Patients were computer-randomised to either a daily home-based aerobic exercise intervention (I), or to usual care (C). The intervention lasted two weeks before surgery and four weeks after discharge from hospital and consisted of medium-intensity aerobic exercise and inspiratory muscle training. Circulating concentrations of IGF-1 and IGFBP-3 were determined by blinded personnel at baseline, time of surgery and 4-6 weeks postoperatively. Primary and secondary outcome measures: The outcome of this subpopulation report was change in IGF-1/IGFBP-3 ratio, IGF-1 and IGFBP-3 concentrations from baseline to surgery, and 4-6 weeks postoperatively. Results: The IGF-1/IGFBP-3 ratio increased from baseline to surgery by 11% in I and 8% in C with no difference between groups (I vs. C: 1.04, 95%CI: 0.97-1.11; p= 1.000). Postoperative change was 5% in I and 3% in C with no difference between groups (I vs. C:1.03, 95%CI: 0.96-1.10; p = 1.000). Results concerning IGF-1 and IGFBP3 also showed statistically significant dynamics over time with no difference between groups. No adverse events were reported. Conclusions: The home-based exercise program in our trial did not have any effect on IGF-1, or IGFBP-3.
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