期刊
GLIA
卷 68, 期 8, 页码 1604-1618出版社
WILEY
DOI: 10.1002/glia.23837
关键词
chromatin remodelers; CNS development; oligodendrogenesis; transcription factors; transcription regulation
资金
- Fondation pour l'Aide a la Recherche sur la Sclerose en Plaques [2014, 2015, 2018, 2019]
- National Institutes of Health [R01NS075243, R01NS072427]
- Fondation pour la Recherche Medicale
- National Multiple Sclerosis Society [RG-1501-02851]
Oligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and chromatin remodeling events. ATP-dependent chromatin remodeling enzymes, which utilize ATP as an energy source to control chromatin dynamics and regulate the accessibility of chromatin to transcriptional regulators, are critical for oligodendrocyte lineage development and regeneration. In this review, we focus on the latest insights into the spatial and temporal specificity of chromatin remodelers during oligodendrocyte development, myelinogenesis, and regeneration. We will also bring together various plausible mechanisms by which lineage specific transcriptional regulators coordinate with chromatin remodeling factors for programming genomic landscapes to specifically modulate these different processes during developmental myelination and remyelination upon injury.
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