期刊
GENETIC EPIDEMIOLOGY
卷 44, 期 6, 页码 629-641出版社
WILEY
DOI: 10.1002/gepi.22292
关键词
blood pressure; gene-environment interaction; lifestyle risk score; loci discovery; multiple lifestyle exposures
资金
- National Heart, Lung, and Blood Institute [N02-HL-64278, R01HL118305, T32HL091823]
- National Institutes of Health [R21 AA024888-01, UL1 TR002345]
- American Heart Association [18CDA34110116]
- NIH [R21 AA024888-01, UL1 TR002345]
- Boston University [N01-HC-25195, HHSN268201500001I]
Although multiple lifestyle exposures simultaneously impact blood pressure (BP) and cardiovascular health, most analysis so far has considered each single lifestyle exposure (e.g., smoking) at a time. Here, we exploit gene-multiple lifestyle exposure interactions to find novel BP loci. For each of 6,254 Framingham Heart Study participants, we computed lifestyle risk score (LRS) value by aggregating the risk of four lifestyle exposures (smoking, alcohol, education, and physical activity) on BP. Using the LRS, we performed genome-wide gene-environment interaction analysis in systolic and diastolic BP using the joint 2 degree of freedom (DF) and 1 DF interaction tests. We identified one genome-wide significant (p < 5 x 10(-8)) and 11 suggestive (p < 1 x 10(-6)) loci. Gene-environment analysis using single lifestyle exposures identified only one of the 12 loci. Nine of the 12 BP loci detected were novel. Loci detected by the LRS were located within or nearby genes with biologically plausible roles in the pathophysiology of hypertension, including KALRN, VIPR2, SNX1, and DAPK2. Our results suggest that simultaneous consideration of multiple lifestyle exposures in gene-environment interaction analysis can identify additional loci missed by single lifestyle approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据