期刊
FUTURE MICROBIOLOGY
卷 15, 期 7, 页码 509-520出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2019-0242
关键词
cervical cancer; domain interactions; gold standard PPI; homology; protein interactions
类别
Aim: HPV is an important cause of cervical cancer, but Chlamydia trachomatis (CT) is suspiciously involved in this disease ranging from direct to its involvement as a cofactor with HPV. We performed this study to understand the interaction of HPV and C. trachomatis with humans and its contribution to cervical cancer. Materials & methods: Host-pathogen and pathogen-pathogen protein-protein interaction maps of HPV/CT/human were prepared and compared to analyze interactions during single/coinfection of C. trachomatis and HPV. The interacting human proteins were detected by their involvement in cervical cancer. Results:C. trachomatis may interact with several cancer associated proteins while HPV and C. trachomatis largely interact with different human proteins, suggesting different pathogenesis. Conclusion:C. trachomatis coinfection with HPV may modulate cervical cancer development.
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