期刊
FUTURE MEDICINAL CHEMISTRY
卷 12, 期 10, 页码 949-959出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2019-0325
关键词
anticancer agents; anti-inflammatory; antimicrobial agents; neuroprotective; steroidal pyrazolines; synthetic techniques
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi, India [09/135/08037/18-EMR-I]
- University Grant Commission (UGC), New Delhi, India under the Research Fellowship in Science for Meritorious Student (RFSMS) scheme [5-94/2007 [BSR]]
Steroidal pyrazolines constitute an interesting and promising scaffold for drug discovery as they display diverse chemical reactivity and a wide range of biological activities. Literature reports indicate potent anticancer potential of steroidal pyrazolines along with broad-spectrum antimicrobial activities. Strong neuroprotective effects with steroids possessing pyrazoline moiety have also been observed. Among all the therapeutically active steroidal pyrazolines, D-ring-substituted derivatives are highly potent and the least toxic. The current and futuristic research approaches in this area are focused towards the exploration of this promising scaffold to develop molecules with widespread pharmacological activities. This review article mainly covers the synthetic and pharmacological aspects of steroidal pyrazolines, which will assist the medicinal chemists working in this area in their scientific endeavors.
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