期刊
FEBS LETTERS
卷 594, 期 13, 页码 2116-2127出版社
WILEY
DOI: 10.1002/1873-3468.13787
关键词
coiled coil; coronin A; Dictyostelium discoideum; multicellular differentiation
资金
- Swiss National Science Foundation
- Novartis Foundation for Bio Medical Research
- EMBO
Coronin proteins are widely expressed among eukaryotic organisms. Most coronins consist of a WD-repeat domain followed by a C-terminal coiled coil. Dictyostelium discoideum expresses a single short coronin coronin A, which has been implicated in both actin modulation and multicellular differentiation. Whether coronin A's coiled coil is important for functionality, as well as the oligomeric state of coronin A is not known. Here, we show that the coiled-coil domain in Dictyostelium coronin A functions in homodimerization, is dispensable for coronin A stability and localization but essential for multicellular differentiation. These results allow a better understanding of the role for the coiled-coil domain of coronin A in oligomerization and demonstrate that its presence is essential for multicellular differentiation.
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