4.6 Article

Comparison of automated and expert human grading of diabetic retinopathy using smartphone-based retinal photography

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EYE
卷 35, 期 1, 页码 334-342

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SPRINGERNATURE
DOI: 10.1038/s41433-020-0849-5

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资金

  1. Knights Templar Eye Foundation Career-Starter Research Grant
  2. University of Michigan Translational Research and Commercialization for Life Sciences
  3. University of Michigan Center for Entrepreneurship Dean's Engineering Translational Prototype Research Fund
  4. QB3 Bridging the Gap Award from the Rogers Family Foundation
  5. Bakar Fellows Award
  6. Chan-Zuckerberg Biohub Investigator Award
  7. National Eye Institute [1K08EY027458]
  8. University of Michigan Department of Ophthalmology and Visual Sciences

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The study aimed to investigate the efficacy of a mobile platform combining smartphone-based retinal imaging with automated grading for determining the presence of referral-warranted diabetic retinopathy. Results showed that automated interpretation achieved a lower sensitivity but higher specificity than trained expert graders, indicating potential for improved efficiency in clinical practice. Feasibility testing with non-ophthalmic personnel in a retina clinic with high disease burden suggested further studies are needed to assess efficacy of screening diabetic patients from general population.
Purpose The aim of this study is to investigate the efficacy of a mobile platform that combines smartphone-based retinal imaging with automated grading for determining the presence of referral-warranted diabetic retinopathy (RWDR). Methods A smartphone-based camera (RetinaScope) was used by non-ophthalmic personnel to image the retina of patients with diabetes. Images were analyzed with the Eyenuk EyeArt (R) system, which generated referral recommendations based on presence of diabetic retinopathy (DR) and/or markers for clinically significant macular oedema. Images were independently evaluated by two masked readers and categorized as refer/no refer. The accuracies of the graders and automated interpretation were determined by comparing results to gold standard clinical diagnoses. Results A total of 119 eyes from 69 patients were included. RWDR was present in 88 eyes (73.9%) and in 54 patients (78.3%). At the patient-level, automated interpretation had a sensitivity of 87.0% and specificity of 78.6%; grader 1 had a sensitivity of 96.3% and specificity of 42.9%; grader 2 had a sensitivity of 92.5% and specificity of 50.0%. At the eye-level, automated interpretation had a sensitivity of 77.8% and specificity of 71.5%; grader 1 had a sensitivity of 94.0% and specificity of 52.2%; grader 2 had a sensitivity of 89.5% and specificity of 66.9%. Discussion Retinal photography with RetinaScope combined with automated interpretation by EyeArt achieved a lower sensitivity but higher specificity than trained expert graders. Feasibility testing was performed using non-ophthalmic personnel in a retina clinic with high disease burden. Additional studies are needed to assess efficacy of screening diabetic patients from general population.

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