期刊
CELLULAR SIGNALLING
卷 28, 期 8, 页码 917-923出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2016.04.005
关键词
beta-Hydroxybutyrate; Signaling; Starvation; Energy expenditure; Autophagy
类别
资金
- CONACYT [220046, 252008]
Ketone bodies beta-hydroxybutyrate (BHB) and acetoacetate are important metabolic substrates for energy production during prolonged fasting. However, BHB also has signaling functions. Through several metabolic pathways or processes, BHB modulates nutrient utilization and energy expenditure. These findings suggest that BHB is not solely a metabolic intermediate, but also acts as a signal to regulate metabolism and maintain energy homeostasis during nutrient deprivation. We briefly summarize the metabolism and emerging physiological functions of ketone bodies and highlight the potential role for BHB as a signaling molecule in starvation response. (C) 2016 Elsevier Inc. All rights reserved.
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