4.5 Review

Targeting the Wnt/β-catenin pathway in neurodegenerative diseases: recent approaches and current challenges

期刊

EXPERT OPINION ON DRUG DISCOVERY
卷 15, 期 7, 页码 803-822

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/17460441.2020.1746266

关键词

Wnt/beta-catenin pathway; neurodegenerative diseases; molecules targeting Wnt signaling; Parkinson's disease; Alzheimer's disease; amyotrophic lateral sclerosis

资金

  1. Institute of Translational Pharmacology (IFT)
  2. National Research Council of Italy (CNR) [DSB.AD007.088]
  3. ARISLA (Project SPLICEALS)
  4. CNR Flagship Project INTEROMICS - PROALS
  5. Ministry of Education, Universities and Research (MIUR) Project [PRIN-2015LFPNMN]

向作者/读者索取更多资源

Introduction: Wnt/beta-catenin signaling is an evolutionarily conserved pathway having a crucial role in embryonic and adult life. Specifically, the Wnt/beta-catenin axis is pivotal to the development and homeostasis of the nervous system, and its dysregulation has been associated with various neurological disorders, including neurodegenerative diseases. Therefore, this signaling pathway has been proposed as a potential therapeutic target against neurodegeneration. Areas covered: This review focuses on the role of Wnt/beta-catenin pathway in the pathogenesis of neurodegenerative diseases, including Parkinson's, Alzheimer's Diseases and Amyotrophic Lateral Sclerosis. The evidence showing that defects in the signaling might be involved in the development of these diseases, and the pharmacological approaches tested so far, are discussed. The possibilities that this pathway offers in terms of new therapeutic opportunities are also considered. Expert opinion: The increasing interest paid to the role of Wnt/beta-catenin pathway in the onset of neurodegenerative diseases demonstrates how targeting this signaling for therapeutic purposes could be a great opportunity for both neuroprotection and neurorepair. Without overlooking some licit concerns about drug safety and delivery to the brain, there is growing and more convincing evidence that restoring this signaling in neurodegenerative diseases may strongly increase the chance to develop disease-modifying treatments for these brain pathologies.

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