期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 38, 期 5, 页码 1851-1859出版社
KARGER
DOI: 10.1159/000443123
关键词
Atherosclerosis; Atherogenesis; Arteries; Lectin-like oxidized low-density lipoprotein receptor-1; LOX-1; Oxidized LDL; OxLDL
资金
- Russian Science Foundation [14-15-00112]
- Russian Federation
In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly up regulated in vascular cells. In atherosclerosis, LOX-1 appears to be the key scavenger receptor for binding oxidized LDL (oxLDL). Notably, a positive feedback exists between LOX-1 and oxLDL. LOX-1 is involved in mediating of proatherosclerotic effects of oxLDL which result in endothelial dysfunction, proinflammatory recruitment of monocytes into the arterial intima, formation of foam cells, apoptosis of endothelial cells (ECs) and vascular smooth muscle cells (VS MCs), as well as in plaque destabilization and rupture. In this review, we consider effects of the LOX-1/oxLDL axis on several types of vascular cells such as ECs, VS MCs, and macrophages. (C) 2016 The Author(s) Published by S. Karger AG, Basel
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