期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 38, 期 3, 页码 993-1002出版社
KARGER
DOI: 10.1159/000443051
关键词
USP14; Cancers; Prognosis; Proliferation; Survival; Apoptosis; Migration
资金
- National Natural Science Foundation of China [81201850]
Background/Aims: Non-small cell lung cancer (NSCLC) tissues overexpress USP14, which promotes tumor cell proliferation and is associated with shorter overall survival time. Methods: The expression of USP14 was assayed in many types of cancers. USP14 was up- and down-regulated using appropriate plasmid or lentiviral vector constructs and its effects on proliferation, cell colony number, and apoptosis rate were measured. A human NSCLC cell line was inoculated into nude mice and the survival rates were recorded. Results: We found USP14 amplification and overexpression in many different cancers. The overexpression of USP14 in USP14 low-expression cell lines promoted cell proliferation and migration, whereas USP14 downregulation suppressed tumor cell proliferation, decreased tumor cell colony number, increased apoptosis rate, and decreased cell migration and invasion. Conclusion: USP14 plays an oncogenic role in various types of cancer, and may thus represent a new cancer therapy target. Copyright (C) 2016 S. Karger AG, Basel
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