期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2020, 期 16, 页码 2439-2447出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202000151
关键词
Acylation; Carbenes; Dihydropyrimidines; Organocatalysis; Oxidation
资金
- University of Ferrara (fondi FAR)
The oxidative N-acylation reaction of 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) with enals and N-heterocyclic carbene (NHC) catalysts is described. The reaction proceeds in the presence of quinone oxidant without additional acyl transfer agents and in the asymmetric variant produces pharmaceutically relevant N3-acylated products with good-to-moderate enantioselectivity.
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