期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 40, 期 6, 页码 1626-1636出版社
KARGER
DOI: 10.1159/000453212
关键词
Betel quid; Drug dependence; Betel quid dependence; Functional connectivity density; Resting-state functional magnetic resonance imaging
资金
- Natural Science Foundation of China [81260218, 81460261]
- Natural Science Foundation of Hainan Province [813201]
- key science and technology project of Hainan Province [ZDXM20120047]
- Social Science development Foundation of Hainan province [SF201312, SF201414]
- Hainan Health Institution Project [2012PT-06]
- National clinical key subject construction project
Objective: Addiction is a chronic relapsing brain disease. Brain structural abnormalities may constitute an abnormal neural network that underlies the risk of drug dependence. We hypothesized that individuals with Betel Quid Dependence (BQD) have functional connectivity alterations that can be described by long- and short-range functional connectivity density(FCD) maps. Methods: We tested this hypothesis using functional magnetic resonance imaging (fMRI) data from subjects of the Han ethnic group in Hainan, China. Here, we examined BQD individuals (n = 33) and age-, sex-, and education-matched healthy controls (HCs) (n = 32) in a rs-fMRI study to observe FCD alterations associated with the severity of BQD. Results: Compared with HCs, long-range FCD was decreased in the right anterior cingulate cortex (ACC) and increased in the left cerebellum posterior lobe (CPL) and bilateral inferior parietal lobule (IPL) in the BQD group. Short-range FCD was reduced in the right ACC and left dorsolateral prefrontal cortex (dIPFC), and increased in the left CPL The short-range FCD alteration in the right ACC displayed a negative correlation with the Betel Quid Dependence Scale (B(JDS) (r= -0.432, P=0.012), and the long-range FCD alteration of left IPL showed a positive correlation with the duration of BQD(r=0.519, P=0.002) in BQD individuals. Conclusions: fMRI revealed differences in long- and short- range FCD in BQD individuals, and these alterations might be due to BQ chewing, BQ dependency, or risk factors for developing BQD. (C) 2016 The Author(s) Published by S. Karger AG, Basel
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