期刊
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
卷 47, 期 12, 页码 2911-2922出版社
SPRINGER
DOI: 10.1007/s00259-020-04788-w
关键词
Tau; PET; [F-18]PI-2620; Perfusion; Neuronal injury
资金
- Projekt DEAL
- Luneburg heritage
- Felgenhauer-Stiftung, Forschungspool Klinische Studien (University of Cologne), H2020, Medtronic and Boston Scientific
- Deutsche Forschungsgemeinschaft (DFG) under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy) [390857198]
- German Federal Ministry of Education and Research (BMBF) [01EK1605A]
- NOMIS foundation (FTLD project)
- GE Healthcare
- Neuropore
Purpose Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several beta-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [F-18]PI-2620 as a potential substitute for [F-18]fluorodeoxyglucose ([F-18]FDG). Methods Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [F-18]PI-2620 tau-PET (0-60 min p.i.) and static [F-18]FDG-PET (30-50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R-1) of [F-18]PI-2620-PET were correlated with corresponding quantification of [F-18]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [F-18]PI-2620 tau-PET and [F-18]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. Results Highest agreement with [F-18]FDG-PET quantification was reached for [F-18]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5-2.5 min SUVr & R-1) displayed strong agreement in all cortical target regions for global mean (R-SUVr 0.76, R-R1 = 0.77) and cerebellar normalization (R-SUVr 0.68, R-R1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [F-18]FDG-PET. There were no relevant differences between more and less experienced readers. Conclusion Early-phase imaging of [F-18]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [F-18]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.
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