期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 200, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2020.112359
关键词
Indole; Alkaloids; Hybrid molecules; Dimer; Metal complex; Anticancer; Drug resistance; Multidrug resistance; Structure-activity relationship; Mechanisms of action
资金
- High-Level Talents Research Fund Project [2019gcky05]
- Education and Teaching reform of Chongqing Institute of Engineering [JY2018205]
Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to anticancer agents represents one of the major obstacles for the effective cancer treatment. Indole derivatives have the potential to act on diverse targets in cancer cells and exhibit promising activity against drug-resistant cancers. Moreover, some indole-containing compounds such as Semaxanib, Sunitinib, Vinorelbine, and Vinblastine have already been applied in clinics for various kinds of cancer even drug-resistant cancer therapy. Thus, indole derivatives are one of significant resources for the development of novel anti-drug-resistant cancer agents. This review focuses on the recent development of indole derivatives with potential therapeutic application for drug-resistant cancers, and the mechanisms of action, the critical aspects of design as well as structure-activity relationships, covering articles published from 2010 to 2020. (C) 2020 Elsevier Masson SAS. All rights reserved.
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