期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 193, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2020.112231
关键词
Autophagy; p62/SQSTM1; mTORC1; NF-kappa B; Nrf2; Tumor
资金
- National Natural Science Foundation of China [81930100, 81773581, 81773639]
- Natural Science Foundation of Jiangsu Province of China [BK20160746]
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2018ZX09711002, 2017ZX09302003]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Double First Class Innovation Team of China Pharmaceutical University [CPU2018GY02]
- Program for Outstanding Scientific and Technological Innovation Team of Jiangsu Higher Education
- Qing Lan Project of Jiangsu Province
- Young Elite Scientists Sponsorship Program by CAST
p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular protein, which interacts with various signaling proteins to regulate a variety of cellular functions. Growing lines of evidence supported a critical role of p62 in tumorigenesis, and p62 may become a therapeutic target for tumor. In this review, we summarize biological functions of structural domains of p62, reported bioactive molecules targeting p62, and the relationship between p62 and tumorigenesis. (c) 2020 Elsevier Masson SAS. All rights reserved.
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