期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 99, 期 4, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2020.151083
关键词
Integrin; Epidermal Growth Factor Receptor (EGFR); Tyrosine kinase inhibitors (TKIs); Epithelial to Mesenchymal Transition (EMT); Resistance
类别
资金
- Zanjan University of Medical Sciences [A-12-802-6, A-12-802-23, A-12-802-26]
Cell adhesion to the extracellular matrix (ECM) is important in a variety of physiological and pathologic processes, including development, tumor invasion, and metastasis. Integrin-mediated attachment to ECM proteins has emerged to cue events primitively important for the transformed phenotype of human cancer cells. Cross-talk between integrins and growth factor receptors takes an increasingly prominent role in defining adhesion, motility, and cell growth. This functional interaction has expanded beyond to link integrins with resistance to Tyrosine kinase inhibitors (TKIs) of Epidermal Growth Factor Receptors (EGERs). In this regard, integrin-mediated adhesion has two separate functions one as a clear collaborator with growth factor receptor signaling and the second as a basic mechanism contributing in Epithelial to Mesenchymal Transition (EMT) which affects response to chemotherapy. This review provides an overview of these mechanisms and describes treatment options for selectively targeting and disrupting integrin interaction to EGFR for cancer therapy.
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