期刊
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
卷 271, 期 1, 页码 211-214出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00406-020-01142-x
关键词
Obsessive-compulsive disorder; Repetitive transcranial magnetic stimulation; Safety; Efficacy
资金
- Concerted Research Action of Ghent University [BOF16/GOA/017]
- Applied Biomedical (TBM) grant of the Agency for Innovation through Science and Technology (IWT), part of the Research Foundation-Flanders (FWO) [B/14730/01]
- het Fonds Wetenschappelijk Onderzoek Rode Neuzen [G0F4617N]
This study found that LF rTMS targeting the dmPFC may improve OCD, anxiety, and depressive symptoms in treatment-resistant OCD patients, and it is a safe and well-tolerated treatment.
Several reports point to the beneficial effects of repetitive transcranial magnetic stimulation (rTMS) in the treatment of resistant obsessive-compulsive disorder (OCD). This study aimed to evaluate the safety and efficacy of rTMS targeting the dmPFC in the treatment of treatment-resistant OCD patients.Twelve patients received 20 sessions of low-frequency (LF) rTMS (1 Hz, 1200 pulses) in a twice daily protocol during 10 weekdays. Y-BOCS and IDS scores modestly but significantly decreased after treatment and at follow-up and HADS anxiety improved at follow-up. LF rTMS may improve OCD, anxiety, and depressive symptoms in treatment-resistant OCD and was a safe and well-tolerated treatment.
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