期刊
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
卷 271, 期 3, 页码 475-485出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00406-020-01128-9
关键词
MECT; MDD; NLRP3; IL-18; NF-kappa b; Cognitive impairment
资金
- Zhejiang Provincial Medical Technology Project [2015KYB351, 2019KY628]
- Natural Science Foundation of Ningbo [2013A610249, 2015A610196]
- Life and Health Technology Innovation Team Fund of Ningbo [2015C110026]
- Ningbo Health Branding Subject Fund [PPXK2018-08]
This study investigated the profiles of inflammatory cytokines and their association with memory function in MECT-treated MDD patients. The results indicated that levels of NLRP3 inflammasome, IL-18, and NF-kappa B significantly increased in MDD patients before and after MECT, and were negatively correlated with total WMS scores. These findings suggest that the disturbed balance of pro-inflammatory and anti-inflammatory mechanisms may contribute to cognitive deficits induced by MECT in MDD patients.
Little is known about the pathophysiology of memory deficits in patients with major depressive disorder (MDD) treated with modified electroconvulsive therapy (MECT). This study examined the profiles of cytokines, the memory function, and their association in MECT-treated MDD patients. Forty first-episode, drug-free MDD patients and 40 healthy controls were recruited. MECT was started with antidepressant treatment at a stable initial dose. The Wechsler Memory Scale (WMS) and Hamilton Rating Scale for Depression 17 (HRSD-17) were used to assess the cognitive function. MDD patients were divided into the memory impairment group (WMS < 50) and the non-memory impairment group (WMS >= 50) based on the total WMS scores after MECT. The levels of NOD-like receptor 3 (NLRP3) inflammasome, interleukin-18 (IL-18) and nuclear factor kappa-B (NF-kappa B) in the serum were measured. MDD patients showed significantly higher levels of NLRP3 inflammasome, IL-18 and NF-kappa B than that in the controls prior to MECT, and the levels also significantly increased after MECT. In MDD patients, the serum levels of these inflammatory cytokines were negatively associated with the total WMS scores and likely contributed to the scores independently. The receiver operating characteristic curve showed that the serum levels of these inflammatory cytokines may predict the cognitive impairment risk in MDD patients receiving MECT. Abnormal levels of NLRP3 inflammasome, IL-18 and NF-kappa B reflecting the disturbed balance of pro-inflammatory and anti-inflammatory mechanisms likely contribute to the MECT-induced cognitive deficits in MDD patients.
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