期刊
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
卷 277, 期 9, 页码 2625-2630出版社
SPRINGER
DOI: 10.1007/s00405-020-06069-6
关键词
Anosmia; COVID-19; Olfactory dysfunction; Loss of smell; SARS-CoV-2; Taste
Purpose The sudden onset of smell and taste loss has been reported as a symptom related to COVID-19. There is urgent need to provide insight to the pandemic and evaluate anosmia as a potential screening symptom that might contribute to the decision to test suspected cases or guide quarantine instructions. Methods Systematic review of the PubMed/Medline, Cochrane databases and preprints up to May 3, 2020. Combined search terms included: COVID-19, SARS-CoV-2, coronavirus, nose, anosmia, hyposmia, olfactory loss, smell loss, taste loss, and hypogeusia. Results Our search identified 18 reviewed articles and 6 manuscript preprints, including a large epidemiological study, four observational case series, five case-controlled studies, five cross-sectional studies, five case series of anosmic patients and four electronic surveys. Great methodological differences were noted. A significant prevalence of anosmia is reported in COVID-19 patients. Controlled studies indicate that anosmia is more common in COVID-19 patients than in patients suffering from other viral infections or controls. Most of the studies reported either smell loss or smell plus taste loss. Less severe COVID-19 disease is related to a greater prevalence of anosmia. A quick recovery of the smell loss may be expected in most COVID-19 cases. Conclusion Anosmia is more prevalent in COVID-19 patients than in patients suffering from other respiratory infections or controls.
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