期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 27, 期 17, 页码 21977-21985出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-020-08636-0
关键词
Hepatotoxicity; Curcumin phytosome; Antioxidants; Apoptosis
资金
- Deanship of Scientific Research at King Khalid University, Abha, KSA [R.G.P.1-117-40]
Increasing entrance of aluminum chloride (AlCl3) in many fields exposes human beings to its biotoxicity. Thereby, the present study assesses the potential ameliorative role of curcumin phytosome (CP) on AlCl3-induced hepatotoxicity. Rats were divided into four groups (n = 6): group 1 served as control; group 2 received CP (200 mg CP/kg b.wt) for 21 days; group 3 injected three doses of AlCl3 (30 mg/kg/body weight) every 5 days intraperitoneally; group 4 received CP for 7 days prior to AlCl3 and then received CP concurrently with AlCl3 for another 14 days. AlCl3 markedly increased (P < 0.05) the concentrations of AST, ALT, ALP, LDH, total bilirubin, and LPO as well as depleted (P < 0.05) albumin, GSH, SOD, and GPx stores in comparison to the control group. These biochemical alterations supported by the lesion observed in histological sections, increasing the expression of caspase-3 and decreasing the expression of Bcl-2. Treatment with CP modulates the hepatic dysfunction, boosting the endogenous antioxidant status, downregulating the expression of caspase-3, and upregulating the expression of Bcl-2. This hepatic ameliorative effect may be mediated by the ability of CP to repair the oxidant/antioxidant equilibrium rather than its ability to suppress apoptosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据