期刊
CELLULAR IMMUNOLOGY
卷 304, 期 -, 页码 59-62出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2016.04.007
关键词
Ezrin; Radixin; Moesin; Neutrophils; Rolling; Migration
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [19590496]
- Grants-in-Aid for Scientific Research [19590496] Funding Source: KAKEN
During inflammation, the selectin-induced slow rolling of neutrophils on venules cooperates with chemokine signaling to mediate neutrophil recruitment into tissues. Previous studies identified P-selectin glycoprotein ligand-1 (PSGL-1) and CD44 as E-selectin ligands that activate integrins to induce slow rolling. We show here that in TNF-alpha-treated cremaster muscle venules, slow leukocyte rolling was impaired in mice deficient in moesin, a member of the ezrin-radixin-moesin (ERM) family. Accordingly, neutrophil recruitment in a peritonitis model was decreased in moesin-deficient mice when chemokine signaling was blocked with pertussis toxin. These results suggest that moesin contributes to the slow rolling and subsequent recruitment of neutrophils during inflammation. (C) 2016 Elsevier Inc. All rights reserved.
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