期刊
CELLULAR IMMUNOLOGY
卷 300, 期 -, 页码 26-32出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2015.11.005
关键词
NKG2C; CD57; CD27; CD28; Cytotoxicity; NKCA; K562; pp65; IE1; Immunosenescence; Aging; Viral load
资金
- NASA [NNX12AB48G]
- NSBRI [PF04307]
- NASA [30923, NNX12AB48G] Funding Source: Federal RePORTER
CMV markedly alters the phenotype and function of NK-cells and T-cells and has been linked to immunosenescence. We show here that subjects with effective CMV control (evidenced by low CMV IgG titers) have functional responses to CMV that are driven by either NKG2C+ NM-cells or CMV-specific T-cells (15 of 24 subjects), but not both. These data indicate that people with effective CMV control are either NM-cell or T-cell responders, and corroborates the idea that NM -cells have rheostat-like properties that regulate anti-viral T-cell responses. Whether or not lifelong CMV control through either NM-cell or T-cell responses have implications for immunosenescence remains to be determined. (C) 2016 Published by Elsevier Inc.
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