4.5 Article

Upregulated CCL28 expression in the nasal mucosa in experimental allergic rhinitis: Implication for CD4+ memory T cell recruitment

期刊

CELLULAR IMMUNOLOGY
卷 302, 期 -, 页码 58-62

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2016.02.001

关键词

Allergic rhinitis; Chemokines; Chemokine receptors; Lymphocyte trafficking; NALT; T cells

资金

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan [25460588]
  2. Grants-in-Aid for Scientific Research [25460588] Funding Source: KAKEN

向作者/读者索取更多资源

During nasal immune responses, lymphocytes activated in the nasopharynx-associated lymphoid tissue (NALT) are thought to traffic to the nasal mucosa. Here we found a prominent infiltration of CD4(+) memory T cells into the nasal mucosa in a mouse model of allergic rhinitis. CCR3 and CCR10 mRNA was increased in the NALT, and CCR3- or CCR10-expressing CD4(+) T cells were present in the nasal mucosa. CCL28, a chemokine ligand for CCR3 and CCR10, was upregulated in nasal epithelial cells. Our results suggest that memory CD4(+) T cells traffic to the nasal mucosa in a process that may involve CCL28 and its receptors CCR3 and CCR10. (C) 2016 Elsevier Inc. All rights reserved.

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