期刊
ENVIRONMENTAL RESEARCH
卷 183, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2020.109264
关键词
Air pollutants; Particulate matter; PM1; Osteoporosis; Rural population
资金
- Foundation of National Key Program of Research and Development of China [2016YFC0900803]
- National Natural Science Foundation of China [81573243, 21806146]
- Henan Provincial Science Fund for Distinguished Young Scholars [164100510021]
- Science and Technology Innovation Talents Support Plan of Henan Province Colleges and Universities [14HASTIT035]
- High-level Personnel Special Support Project of Zhengzhou University [ZDGD13001]
- Career Development Fellowship of the Australian National Health and Medical Research Council [APP1107107, APP1163693]
- Early Career Fellowship of Australian National Health and Medical Research Council [APP1109193]
Objectives: The associations of long-term exposure to air pollution with osteoporosis are rarely reported, especially in rural China. This study aimed to explore the association among rural Chinese population. Methods: A total of 8033 participants (18-79 years) derived from the Henan Rural Cohort Study (n = 39,259) were included in this cross-sectional study. Exposure to air pollutants was estimated using machine learning algorithms with satellite remote sensing, land use information, and meteorological data [including particulate matter with aerodynamic diameters <= 1.0 mu m (PM1), <= 2.5 mu m (PM2.5), and <= 10 mu m (PM10), and nitrogen dioxide (NO2)]. The bone mineral density of each individual was measured by using ultrasonic bone density apparatus and osteoporosis was defined based on the T-score <= -2.5. Multiple logistic regression models were used to examine the association of air pollution and osteoporosis prevalence. Results: We observed that per 1 mu g/m(3) increase in PM1, PM2.5, PM10 and NO2 were associated with a 14.9%, 14.6%, 7.3%, and 16.5% elevated risk of osteoporosis. Compared with individuals in the first quartile, individuals in the fourth quartile had higher odds ratio (OR) of osteoporosis (P-trend < 0.001), the ORs (95% confidence interval) were 2.08 (1.72, 2.50) for PM1, 2.28 (1.90, 2.74) for PM2.5, 1.93 (1.60, 2.32) for PM10, and 2.02 (1.68, 2.41) for NO2. It was estimated that 20.29%-24.36% of osteoporosis cases could be attributable to air pollution in the rural population from China. Conclusions: Long-term exposure to air pollutants were positively associated with high-risk of osteoporosis, indicated that improving air quality may be beneficial to improve rural residents health.
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