期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 73, 期 10, 页码 2053-2077出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2168-3
关键词
Neuron; Development; Polarity; Cytoskeleton; Microtubule; Plus; end tracking proteins; EB; CLIP; CLASP
Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders.
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