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CELLULAR AND MOLECULAR LIFE SCIENCES (2015)
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JOURNAL OF LEUKOCYTE BIOLOGY (2014)
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ONCOGENE (2014)
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Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis
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SOCS3 Transactivation by PPARγ Prevents IL-17-Driven Cancer Growth
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CANCER RESEARCH (2013)
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
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DIABETES (2013)
Myeloid depletion of SOCS3 enhances LPS-induced acute lung injury through CCAAT/enhancer binding protein delta pathway
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FASEB JOURNAL (2013)
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FEBS LETTERS (2013)
Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma
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JOURNAL OF GENERAL VIROLOGY (2013)
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PLOS ONE (2013)
Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis
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PLOS PATHOGENS (2013)
Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function
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ARTHRITIS AND RHEUMATISM (2012)
Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: A cross-sectional study
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GROWTH FACTORS (2012)
Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
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The SOCS boxuAdapting proteins for ubiquitination and proteasomal degradation
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IUBMB LIFE (2012)
Suppressor of Cytokine Signaling 3 Inhibits Breast Tumor Kinase Activation of STAT3
Yiwei Gao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation
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JOURNAL OF IMMUNOLOGY (2012)
Loss of Expression and Function of SOCS3 Is an Early Event in HNSCC: Altered Subcellular Localization as a Possible Mechanism Involved in Proliferation, Migration and Invasion
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PLOS ONE (2012)
Dysregulation of Suppressor of Cytokine Signaling 3 in Keratinocytes Causes Skin Inflammation Mediated by Interleukin-20 Receptor-Related Cytokines
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PLOS ONE (2012)
Regulation of Insulin and Leptin Signaling by Muscle Suppressor of Cytokine Signaling 3 (SOCS3)
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PLOS ONE (2012)
Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation
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FRONTIERS IN IMMUNOLOGY (2012)
SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation
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ACTA NEUROPATHOLOGICA (2011)
Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways Regulation of T-Cell Inflammation by SOCS1 and SOCS3
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
Docosahexaenoic acid: A natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects
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BIOFACTORS (2011)
Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction
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CANCER LETTERS (2011)
A Critical Role for SOCS3 in Innate Resistance to Toxoplasma gondii
Ryan J. Whitmarsh et al.
CELL HOST & MICROBE (2011)
Lactobacillus rhamnosus GG and Streptococcus thermophilus induce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages
S. Latvala et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2011)
HIV interferes with SOCS-1 and-3 expression levels driving immune activation
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EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma
Kota Iwahori et al.
INTERNATIONAL JOURNAL OF CANCER (2011)
The PPE18 Protein of Mycobacterium tuberculosis Inhibits NF-κB/rel-Mediated Proinflammatory Cytokine Production by Upregulating and Phosphorylating Suppressor of Cytokine Signaling 3 Protein
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JOURNAL OF IMMUNOLOGY (2011)
Viral Exploitation of Host SOCS Protein Functions
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JOURNAL OF VIROLOGY (2011)
Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer
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MOLECULAR BIOSYSTEMS (2011)
MECHANISMS OF DISEASE The Pathogenesis of Rheumatoid Arthritis
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NEW ENGLAND JOURNAL OF MEDICINE (2011)
Tyrosine phosphatases in the HER2-directed motility of ovarian cancer cells: Involvement of PTPN12, ERK5 and FAK
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ANALYTICAL CELLULAR PATHOLOGY (2011)
Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11
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FEBS LETTERS (2010)
Impairment of Gamma Interferon Signaling in Human Neutrophils Infected with Anaplasma phagocytophilum
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INFECTION AND IMMUNITY (2010)
Vesicle-associated Membrane Protein (VAMP) Cleavage by a New Metalloprotease from the Brazilian Scorpion Tityus serrulatus
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma
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JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)
Suppressor of Cytokine Signaling 3 Inhibits Antiviral IFN-β Signaling To Enhance HIV-1 Replication in Macrophages
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JOURNAL OF IMMUNOLOGY (2010)
Suppressor of Cytokine Signaling 3 Suppresses Hepatitis C Virus Replication in an mTOR-Dependent Manner
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JOURNAL OF VIROLOGY (2010)
Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling
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EXPERIMENTAL BIOLOGY AND MEDICINE (2009)
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INTERNATIONAL JOURNAL OF CANCER (2009)
IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway
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JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection
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JOURNAL OF HEPATOLOGY (2009)
CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression
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JOURNAL OF LEUKOCYTE BIOLOGY (2009)
The SOCS Box Encodes a Hierarchy of Affinities for Cullin5: Implications for Ubiquitin Ligase Formation and Cytokine Signalling Suppression
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JOURNAL OF MOLECULAR BIOLOGY (2009)
Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines
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NATURE MEDICINE (2009)
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TRENDS IN IMMUNOLOGY (2009)
Respiratory Syncytial Virus Proteins Modulate Suppressors of Cytokine Signaling 1 and 3 and the Type I Interferon Response to Infection by a Toll-Like Receptor Pathway
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Splenic Suppressor of Cytokine Signaling 3 Transgene Expression Affects T Cell Responses and Prevents Development of Collagen-Induced Arthritis
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ARTHRITIS AND RHEUMATISM (2008)
SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro
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BMC CANCER (2008)
The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients
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CLINICAL AND EXPERIMENTAL MEDICINE (2008)
The many faces of the SOCS box
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CYTOKINE & GROWTH FACTOR REVIEWS (2008)
Suppressor of cytokine signaling 1 inhibits IFN-γ inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation
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FASEB JOURNAL (2008)
Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins
Alexander Dalpke et al.
IMMUNOBIOLOGY (2008)
NOTCH1 up-regulation and signaling involved in Mycobacterium bovis BCG-induced SOCS3 expression in macrophages
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-β1/Smad3 signaling
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MOLECULAR IMMUNOLOGY (2008)
SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag
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Respiratory syncytial virus (RSV) attachment and nonstructural proteins modify the type I interferon response associated with suppressor of cytokine signaling (SOCS) proteins and IFN-stimulated gene-15 (ISG15)
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PLOS PATHOGENS (2008)
Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma
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Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy
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Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells
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JOURNAL OF IMMUNOLOGY (2007)
JAK-STAT signaling: From interferons to cytokines
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase
Joanne Elliott et al.
JOURNAL OF VIROLOGY (2007)
The dual function of hepatic SOCS3 in insulin resistance in vivo
Takehiro Torisu et al.
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JOURNAL OF INFECTIOUS DISEASES (2007)
Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C
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GASTROENTEROLOGY (2007)
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ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2007)
SOCS proteins, cytokine signalling and immune regulation
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Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic
Yang Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
General nature of the STAT3-activated anti-inflammatory response
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JOURNAL OF IMMUNOLOGY (2006)
Regulation of the tonsil cytokine milieu favors HIV susceptibility
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JOURNAL OF LEUKOCYTE BIOLOGY (2006)
Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease:: a possible role for suppressors of cytokine signaling 1 and 3
Vida A. Dennis et al.
INFECTION AND IMMUNITY (2006)
Suppressor of cytokine signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Helle Frobose et al.
MOLECULAR ENDOCRINOLOGY (2006)
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
Peter K. K. Wong et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Zhi Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-β1
I Kinjyo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance
H Shi et al.
DIABETES (2006)
Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells
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CANCER LETTERS (2006)
The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model
A Ozaki et al.
JOURNAL OF IMMUNOLOGY (2005)
SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition
A Weber et al.
ONCOGENE (2005)
JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3
A Yadav et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Defective Jak-Stat activation in hepatoma cells is associated with hepatitis C viral IFN-α resistance
HZ Zhu et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2005)
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis
D Jo et al.
NATURE MEDICINE (2005)
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication
S Yokota et al.
VIROLOGY (2005)
SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells
D Hebenstreit et al.
MOLECULAR IMMUNOLOGY (2005)
Tumour necrosis factor α (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver:: relevance of suppressors of cytokine signalling
G Sass et al.
BIOCHEMICAL JOURNAL (2005)
The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression
NJ Stevenson et al.
JOURNAL OF IMMUNOLOGY (2004)
Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients
J Rieusset et al.
DIABETES (2004)
Influenza: old and new threats
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NATURE MEDICINE (2004)
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway
S Yokota et al.
JOURNAL OF VIROLOGY (2004)
Suppressors of cytokine signalling and regulation of growth hormone action
CJ Greenhalgh et al.
GROWTH HORMONE & IGF RESEARCH (2004)
Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis - Exacerbation of joint inflammation in STAT-1 gene-knockout mice
ASK de Hooge et al.
ARTHRITIS AND RHEUMATISM (2004)
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
B He et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor β2 subunit
K Yamamoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Negative regulation of FAK signaling by SOCS proteins
E Liu et al.
EMBO JOURNAL (2003)
Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells
CR Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
Y Seki et al.
NATURE MEDICINE (2003)
FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma
T Miyazaki et al.
BRITISH JOURNAL OF CANCER (2003)
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
H Yasukawa et al.
NATURE IMMUNOLOGY (2003)
Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
JJ Senn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3
LA Denson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially cytokine signaling 3
C Niemand et al.
JOURNAL OF IMMUNOLOGY (2003)
Regulatory effect of SOCS on NF-κB activity in murine monocytes/macrophages
SH Park et al.
DNA AND CELL BIOLOGY (2003)
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
LY Rui et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
T Atsumi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
The effect of suppressor of cytokine signaling 3 on GH signaling in β-cells
SG Ronn et al.
MOLECULAR ENDOCRINOLOGY (2002)
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction
M Hörtner et al.
JOURNAL OF IMMUNOLOGY (2002)
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities
D De Souza et al.
BIOCHEMISTRY (2002)
Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: Implications for Th cell lineage commitment and maintenance
CE Egwuagu et al.
JOURNAL OF IMMUNOLOGY (2002)
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
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JOURNAL OF CLINICAL INVESTIGATION (2001)
Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses
A García-Sastre
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Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase
M Emanuelli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
SOCS proteins: Negative regulators of cytokine signaling
DL Krebs et al.
STEM CELLS (2001)
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
C Bjorbæk et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The suppressors of cytokine signaling (SOCS) proteins: Important feedback inhibitors of cytokine action
NA Nicola et al.
EXPERIMENTAL HEMATOLOGY (2000)
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
SE Nicholson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
J Schmitz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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