期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 74, 期 8, 页码 1503-1509出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2414-8
关键词
B cell; Immunometabolism; IgA antibody; Lipid; Commensal bacteria; Glycolysis; TCA cycle; Vitamin B1; Mucosal vaccine; Signaling
资金
- MEXT/JSPS KAKENHI [26293111, 16H01373, 15H05790]
- Ministry of Health, Labour and Welfare (MHLW)
- Research on Development of New Drugs
- Japan Agency for Medical Research and Development (AMED)
- Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food Industry
- Astellas Foundation for Research on Metabolic Disorders
- Terumo Foundation for Life Sciences and Arts and Suzuken Memorial Foundation
- Grants-in-Aid for Scientific Research [15H05790, 16H01373, 26293111] Funding Source: KAKEN
To sustain the bio-energetic demands of growth, proliferation, and effector functions, the metabolism of immune cells changes dramatically in response to immunologic stimuli. In this review, I focus on B cell metabolism, especially regarding the production of intestinal IgA antibody. Accumulating evidence has implicated not only host-derived factors (e.g., cytokines) but also gut environmental factors, including the possible involvement of commensal bacteria and diet, in the control of B cell metabolism during intestinal IgA antibody production. These findings yield new insights into the regulation of immunosurveillance and homeostasis in the gut.
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