期刊
CELLULAR AND MOLECULAR BIOENGINEERING
卷 9, 期 2, 页码 252-257出版社
SPRINGER
DOI: 10.1007/s12195-016-0431-1
关键词
Nuclear envelope; LINC complex; Membrane; Geometry
资金
- NSF [CMMI 1437330]
- NIH [R01 EB014869, R01 GM102486]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1437395] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1437330] Funding Source: National Science Foundation
The nuclear envelope segregates the nucleoplasm from the cytoplasm and is a key feature of eukaryotic cells. Nuclear envelope architecture is comprised of two concentric membrane shells which fuse at multiple sites and yet maintain a uniform separation of 30-50 nm over the rest of the membrane. Studies have revealed the roles for numerous nuclear proteins in forming and maintaining the architecture of the nuclear envelope. However, there is a lack of consensus on the fundamental forces and physical mechanisms that establish the geometry. The objective of this review is to discuss recent findings in the context of membrane mechanics in an effort to define open questions and possible answers.
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