期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 14, 期 1, 页码 4-13出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cmi.2016.06
关键词
DNA sensing; evasion; innate immunology; STING
类别
资金
- Danish Medical Research Council [12-124330]
- Novo Nordisk Foundation
- Lundbeck Foundation [R198-2015-171]
- Aarhus University Research Foundation
- Faculty of Health Sciences, Aarhus University
- Lundbeck Foundation [R198-2015-171] Funding Source: researchfish
Cellular sensing of virus-derived nucleic acids is essential for early defenses against virus infections. In recent years, the discovery of DNA sensing proteins, including cyclic GMP-AMP synthase (cGAS) and gamma-interferon-inducible protein (IFI16), has led to understanding of how cells evoke strong innate immune responses against incoming pathogens carrying DNA genomes. The signaling stimulated by DNA sensors depends on the adaptor protein STING (stimulator of interferon genes), to enable expression of antiviral proteins, including type I interferon. To facilitate efficient infections, viruses have evolved a wide range of evasion strategies, targeting host DNA sensors, adaptor proteins and transcription factors. In this review, the current literature on virus-induced activation of the STING pathway is presented and we discuss recently identified viral evasion mechanisms targeting different steps in this antiviral pathway.
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